Products: PDx-Pop®
TOOLS FOR EXPEDITING POPULATION ANALYSIS

Harness the power of NONMEM®
Expedite modeling and analysis

PDx-Pop software seamlessly integrates with existing tools to expedite the iterative process of population pharmacokinetic modeling and analysis. Working in concert with NONMEM®, the "gold standard" in Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic modeling, MS Excel® and S-PLUS® Analytic Software, PDx-Pop delivers optimal flexibility, increased efficiency and added functionality.



Features

Improved Modeling Management
Enhanced Data Management and Exploration
Efficient Post-Processing
Enhanced Report-Friendly Outputs
Automated Model Evaluation Methods
Tracking and Audit Trail
Detailed Help System



New features available in PDx-Pop Version 3.0:

1. Windows Vista compatibility.
2. Linux Version (tested on Ubuntu and Redhat).
3. Mac OS X version (tested on Tiger).
4. A new real time plotting feature has been added that can plot the objective function value as a function of the iteration number to allow the user to monitor the progress of the run graphically.
5. A new data checkout plotting system with additional capability that can use either R or S-Plus has been added to supplement the current data checkout using Microsoft Excel.*
6. New automated plots for individual parameter estimates (QQ-plots, QQ-log plots, and histograms of parameters).
7. New automated plots for individual eta estimates (pairs plots, QQ-Plots and histograms of etas).
8. To accommodate security measures for our clients, PDx-Popimplements a new, more user-friendly licensing mechanism that does not require administrative user privileges.
9. Installation is simplified and no longer requires the long serial number.

* Integration of PDx-Pop with R (for statistics and graphics) and xpose4 was introduced in PDx-Pop version 2.2



System Requirements

Recommended system requirements to run PDx-Pop with other required software:
Intel or AMD pentium processor with 1 GB of memory (2 GB for Windows Vista)
Windows 2000, XP, or Vista
SuperVGA or other Windows-compatible graphics card and monitor
CD-ROM disk drive
Microsoft mouse or other compatible pointing device
Supports all compatible printers
100 MB free disk space for all required software (Interface space = 25 MB)
~100 MB of swap space/virtual memory



Required Software

NONMEM V Level 1.1 or NONMEM VI
Compaq/Digital Visual Fortran (Versions 5.0 through 6.6), Intel Fortran 7.x - 10.x for Windows, or GNU Foundation g77 compilers
MS Excel 97-2000-XP-2003-2007 and Word 97-2000-XP-2003-2007



Recommended Software

S-PLUS 6.2 or higher for Windows or R Statistical and Graphics Software (2.5.0 or higher)
Xpose 3.1 (S-PLUS Script, Niclas Jonsson, University of Uppsala, for processing of NONMEM data and table files) or Xpose 4 for R



Licensing

PDx-Pop seat licenses are purchased on an annual basis.

The base unit of purchase is a 3-seat annual license, with the ability to purchase individual annual seat licenses after base purchase for that year.

PDx-Pop licensees are entitled to the following benefits:
full customer support
automatic updates and upgrades, exclusive of new functionality
advanced notice and priority shipment of new products and version releases



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