PRODUCT DEVELOPMENT SERVICES
Clinical Pharmacodynamics

In recent years there has been increasing interest in the application of biomarkers and surrogate endpoints in healthy volunteer studies to provide pivotal information on efficacy, dose-response and time-effects of drugs. ICON has worked extensively in this area, developing and validating models for investigating a range of therapeutic targets, as part of its own research and development efforts and in partnership with Sponsors.

Current Models Include:

	Acute Pain
Cold Pain Test    Heat Pain Detection Threshold    Heat Pain Tolerance    Brief Thermal Stimulation
	Chronic Pain
Intradermal Capsaicin Model    Hyperalgesia    Allodynia    Pain VAS    Flare Measurement    Heat Hyperalgesia    Topical Capsaicin Model    Heat Capsaicin Model    Quantitative Sensory Testing (QST)    Perception Thresholds    Heat detection    Cold detection    Wind up ratio    Mechanical pain threshold/sensitivity    Pressure pain threshold    UVB/C Burn Model (in development)
	Inflammatory Response
Cantharidin Blister Model
	Anxiety Models
Simulated Public Speaking    Aversive Conditioning    CO2 - Induced Anxiety
	Test Meal Model
Universal Eating Monitor    Validated Questionnaires    Bioelectrical Impedence    Food Diaries
	Diabetes
Glucose Clamp
	Sexual Dysfunction
Ejaculatory Latency Model
	Cognition
Scopolamine Model