Tip # 20 -
Notes on changing NONMEM V *SIZE S parameters
--> Revised July 18, 2005:
Due to the recent traffic on the nmusers list, this tip is
being issued so
that users become aware that changing these parameters should
not be done
"in a vacuum". The most commonly changed NONMEM V *SIZES parameters
and how
they may be calculated are tabulated below. See NONMEM Users
Guide - Part
III, Appendix 2 for the files in which they occur.
Cautionary Note: IT IS NOT RECOMMENDED THAT YOU CHANGE THESE
VALUES UNLESS
YOU HAVE A NEED TO DO SO AND YOU KNOW WHAT YOU ARE DOING!
Also note that
there is an interdependence between paramaters which may require
multiple
parameters to be changed when certain sizes are exceeded (as
indicated by
error messages from NONMEM or NM-TRAN).
LTH: max. no. of theta's (user-defined, defualt is 40)
LVR: max. no. of eta's and epsilon's (user-defined, default is 30)
LVR2: max. no. of eta's permitted when Laplacian method is
used
(user-defined, default is 10)
LPAR: max. no. of parameters that may be estimated,
LPAR=LTH + LVR + off-diagonal variances
(e.g. 50 off-diagonal variances would allow
a full 10 x 10 diagonal matrix to be estimated)
(user-defined, default is 70)
LPAR2: LPAR2=I*(I+1)/2 where I=INT(SQRT(2*LPAR)) - round up
to next integer,
(the FORTRAN default is variables starting with I through
N are integers)
(default is 66)
LPAR3: max. of 2850 or LPAR*(LPAR+1)/2 (default is 2850)
NO: max. no. of observation records/individual (default is
50)
LWS1: Size of working space 1, max. of LPAR2*(5*LPAR2+5),
5*(LTH+LVR)*(LTH+LVR+1), or INT(1.2*LVR*(LVR+1)) (default
is 3500)
LADD: Related to L2 data item, NO*(NO+1)/2*NDBSb+100, (+100
selected as
arbitrary factor to exceed NO*(NO+1)/2*NDBS) (default is 2550)
(NDBS is no. of diagonal blocks of SIGMA matrix)
(This tip is supplied "gratis" and without implicit or explicit
support from
GloboMax LLC).
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