PRODUCTS: NONMEM® USER TIPS

These tips are brought to you as information of interest from experiences in using NONMEM. All tips can also be found in the tips folder on the NONMEM Repository@GloboMax.

Tip # 12 - NONMEM using g77 for Windows:

A free FORTRAN compiler for the Microsoft Windows environment is available from the Free Software Foundation (GNU). A G77 for Win32 (Windows 95/NT) package is available from http://kkourakis.tripod.com/g77.htm.

There are three zip files:
g77exe.zip   [1,574Kb]   The main executables
g77lib.zip   [208Kb]   The libraries
g77doc.zip   [301Kb]   Documentation and other stuff

You may also need the free 32-bit "unzip.exe" utility that's available from the same location (unzip.zip). All four files are also available on the NONMEM@GloboMax Repository.

Install the compiler as instructed and remember to run g77setup.bat each time before using the g77 compiler and/or NONMEM (the prefered method is to add the contents of the batch file to your environment variables). The compiler appears to operate much like the G77 for LINUX and UNIX compilers.

After installing the g77 compiler, NONMEM can be installed and run using the following instructions. [Adding the g77 environmental variables to your system is recommended so that you can avoid having to run the g77setup.bat file every time you run NONMEM.] You will need three files in addition to the NONMEM distribution files - SETUP.bat, NMG77.bat and MAKEG77BAT.

These three files are available from the NONMEM@GloboMax Repository.

NONMEM Installation with g77 for Windows

  1. Create a directory for the g77 NONMEM install, e.g. c:\nmvg77, and copy the three files, SETUP.bat, NMG77.bat and MAKEG77BAT (no file extension), to that directory. (Use your NONMEM installation diskettes for the remaining files or copy the files from the install directory of an existing installation previously created using setup.bat, e.g. from c:\nmv.) [Use caution no to overwrite the new setup.bat if you copy files from another directory or diskette.]
  2. Make sure g77setup.bat (the file that sets the g77 environmental variables) is run prior to the installation and prior to all NONMEM runs OR add the FORTRAN environmental variables to your environment permanently.
  3. From a DOS window and in the install directory, run the new setup.bat installation using appropriate arguments, e.g. setup a c nmvg77 g77 y

    where
    a is the diskette drive
    c is the hard drive
    nmvg77 is the install directory
    g77 is the compiler command
    y is optimization
  4. At the step 6 "pause" of setup.bat, make the changes to blkdat.for and flu.for in c:\nmvg77\nm\ specified below and then let the batch program resume (by pressing any key):

    BLKDAT.FOR line 26: Change 'con' to 'nul'. Note that this change stops attempts to display intermediate output to the console. There is a problem in g77 which does not permit intermediate output (FNINT) to to be directed to the DOS console device 'con'.

    FLU.FOR line 10: Change "COMMITQQ(I)" to "FLUSH(I)" This change reflects a difference in dialect for the function which flushes a file output buffer.
  5. Test the installation by running control5 from the command line, using the nmfe5.bat found in c:\nmg77\run, e.g.:

    c:\nmg77\run> nmfe5 control5 report5

    [Note: The choice of compiler used to run NONMEM is left to the discretion of the individual user. This tip is not intended to endorse or discourage use of any particular compiler or vendor. It's sole intent is to inform users and increase the awareness of available options for running NONMEM. It is the responsibility of the end-user to ascertain that the installation was successful and that the compiler generates appropriate results.]