ICON Development Solutions is pleased to announce its
agreement with the Regents of University of California at
San Francisco to become the licensor of NONMEM, the “gold
standard” software package for Population Pharmacokinetic/Pharmacodynamic
data analyses.
Since 1979, the NONMEM Project at the University
of California at San Francisco has been concerned with the
development of data analysis techniques and exportable software
for estimating the parameters of nonlinear mixed effects (statistical
regression-type) models. These techniques are particularly
useful when the data are population pharmacokinetic/pharmacodynamic
data, and when there are only a few PK/PD measurements from
some individuals sampled from the population, or when the
regression design varies considerably between individuals.
However, increasingly, the techniques are also being used
advantageously with better-designed experimental type data.
Find out about PDx-Pop®, Harnessing
the power of NONMEM, Expediting Population Modeling and Analysis.
The Software:
The NONMEM computer program is written and distributed in
ANSI FORTRAN 77 code and, therefore, can be used with any
hardware and operating system incorporating a FORTRAN 77 compiler
adhering to the ANSI standard. Since a NONMEM run can take
considerable CPU time, perhaps many hours, depending on the
speed of the computer and the size of the problem, it is advisable
to use a fast machine. In addition to fast time-shared machines,
32-bit PC's are commonly used, as are RISC machines of different
sorts.
NONMEM is an evolving program, reflecting
tested methodological and programming improvements. The software
consists of three parts: (i) NONMEM itself, the basic and
very general nonlinear regression program, (ii) PREDPP, a
very powerful package of subroutines handling population PK
data, which can free the user from coding any kinetic type
equations him/herself, while simultaneously allowing complicated
patient-type data to be easily used, and (iii) NM-TRAN, a
preprocessor allowing control and other needed inputs to be
specified in a user-friendly manner. Both NONMEM and NM-TRAN
are batch type programs.
Licensing:
The NONMEM program is available on CD ROM in ASCII
format, or on CD ROM with DOS or UNIX-tar
format, which together with the documentation and all updates
and additions to the program and documentation, will be delivered
for a license royalty fee to be paid annually. This fee is
subject to change from year to year, and at each anniversary
the licensee at its option may choose not to renew the license.
NONMEM Technical Support (Program Installation and operation)
Telephone: +1 410-696-3098
The Official
Bug Lists:
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PRODUCTS:
NONMEM®